Common Name(s): Coracaozinho, Erva-de-jaboti, Erva-de-jabuti, Erva-de-vidro, Lingua de sapo, Shiny bush, Silver bush Medically reviewed by Drugs.com. 1: EFFECT OF THE ETHANOLIC EXTRACT OF PEPEROMIA PELLUCIDA (LEAF AND STEM) ON ORAL GLUCOSE TOLERANCE TEST IN DIABETIC MICE. Despite its wide range of folk medicinal uses in India sub-continent, there is very little scientific documentation available on its pharmacological and biological activities as well as its chemical constituents. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Keywords :Peperomia pellucida (L.) Kunth, acute toxicity, methanol extract, LD 50. Phytochem 2001; 54: 547-551. Am J PhysiolEndocrinolMetab. L also had shown the presence of alkaloid, tannins, steroids and carbohydrates etc. Mofizur Rahaman 2 and Sangita Paul Kundu 3, Department of Pharmacy, Bangladesh Institute of Medical  Science (BIMS) 1, N/23 Nurjahan Road, Mohammadpur, Dhaka, Bangladesh, Department of Pharmacy, Bangladesh University 2, Mohammadpur, Dhaka, Bangladesh, Department of Pharmacy, University of Dhaka 3, Dhaka, Bangladesh. In addition, the plant extract of Peperomia pellucida gave positive reactions for rdiac glycosides from slightly present to … Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Review. In normal condition, insulin increases the receptor-mediated removal of LDL-cholesterol and decreased activity of insulin during diabetes causes hypercholesterolemia. Blood samples analyzed for blood glucose content by using OK meter Match glucose test meter (Hsinchu, Taiwan). showed positive reactions for saponins, tannins, flavonoids, phylobatanins, alkaloids glycosides and cardiac glycosides from slightly present to highly present (table 1). 3.2. Am J Physiol. Plant Materials: Peperomia pellucida were collected from the side of the river in Fakirhat, Khulna, Bangladesh during the month of October in 2011 and the plant authenticity were confirmed from the Bangladesh National Herbarium, Mirpur, Dhaka. Uses, Benefits, Cures, Side Effects, Nutrients in Peperomia Pellucida. 1% Tween 80 solution in water (10 ml/ kg; P.O.). Such pain stimulus leads to the release of free arachidonic acid from phospholipids33 .The acetic acid-induced writhing model response is a sensitive procedure to evaluate peripherally acting analgesic. 2008 Nov; 56(11):2045-2052. It is crushed and mixed with water to form a mixture, heated and administered orally to cure hemorrhage. Peperomia pellucida is an annual herb that is widely distributed in many South American and Asian countries (4). Preliminary photochemical screening reveals the presence of flavonoid, steroid, alkaloid, tannin and saponin in the plant extract. 2005 Sep;19(5):389-397. "The antibacteial activity of, Ragasa CY, Dumato M, Rideout JA (1998). 1 aktivitas antioksidan, kadar fenolik, dan flavonoid total tumbuhan suruhan (peperomia pellucida l. kunth) elsha ukieyanna departemen biokimia fakultas matematika dan ilmu pengetahuan alam institut pertanian bogor bo JAMA. CONCLUSION: The research work was undertaken to evaluate the hypoglycemic properties of different parts of the plant Peperomia pellucida in alloxan-induced diabetic mice, analgesic and also anti-inflammatory effects. 2007 Aug; 293(2):E453-9. Acetic acid-induced writhing model represent pain sensation by triggering localized inflammatory response. Analgesic effect of Peperomia pellucida extract on acetic acid induced writhing in mice: Table 3 shows the effects of the extract of an acetic acid-induced writhing in mice. Clinical Overview Use. Ghani A. Research reveals no clinical data regarding the use of P. pellucida as an analgesic agent. Hypoglycemic test when performed with the extract showed more improvement compared with that without the extract (DC group). Betel water (Peperomia pellucida) is a type of plant that grows in Java and can live in all conditions (Wijaya and Monica, 2004). With plant extracts might increase the level of enzyme to the control level indicating an over-all increase in glucose influx. .Intraperitoneal administration of ethanolic extracts of Peperomia pellucidaresulted in significant reduction of serum lipid levels in mice with hyperlipidemia viz. This study aims to establish the non-specific and specific parameters of ethanol extract … Herbal materials susceptible to contamination during processing and storage which can shortens their shelf life. The effects of extracts on blood sugar levels are dose dependent. Eight Wistar rats received oral indomethacin 10 mg/kg as a control; another group of rats received P. pellucida aqueous extract 400 mg/kg for all 4 distinct phenophases 1 hour before subplantar injection of 1% carrageenan 0.1 mL/paw. Last updated on Mar 20, 2020. 6 bakteri. The same test, when repeated in another study, attained higher inhibition percentages (78%) when a methanolic extract of P. pellucida 210 mg/kg was used. Background: Peperomia pellucida is an economic plant grown in West Africa. J Leukoc Biol. Introduction: Peperomia pellucida L. Kunth has been reported to have some biological activities such as antihypertensive and antioxidants. Peperomia pellucida extracts contain the presence of flavonoids and related phenolic compounds. In our study, it is found that various fractions have also hypoglycemic effect in glucose induced hyperglycemic mice. Am J PhysiolEndocrinolMetab. The mechanism of action is associated with prostaglandin synthesis interference, as confirmed by results of an arachidonic acid-induced rat paw edema study.Arrigoni-Blank 2002, de Fatima 2004. No clinical data have been reported on human toxicity. Aim: We investigated the phytochemical and antimicrobial activity of N-hexane, Ethyl acetate, and Ethanol extract of Peperomia pellucida whole plant that grows around Ado-Ekiti, Ekiti State, Nigeria. Alloxan monohydrate was purchased from Loba chemie, India.Carrageenan was purchased from Otta chemika, India. Hasib Sheikh*, Shotabdi Sikder , Sagar Kumar Paul , A.M. Rashedul Hasan , Md. Muñoz V, Sauvain M, Bourdy G, et al. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise? The species develops during rainy periods (often in the spring) and thrives in loose, humid soils under the shade of trees. Information regarding pregnancy and lactation is lacking. Arrigoni-Blank Mde F , Oliveira RL , Mendes SS . This may be due to the presence of hypoglycemic flavonoids, triterpines or saponin glycosides that also requiring further investigation. Phytosterols such as … After 7 days of treatment with extracts, glucose levels were significantly lowered in Group-DPP (300mg/kg). is a wild plant that can be found in various shaded and damp habitats in tropical and subtropical climate. Peperomia pellucida extracts contain the presence of flavonoids and related phenolic compounds. The objective of this study was to isolate ACE inhibitor from aerial part of the plant. 2005 Oct; 60(10): 1315-1318. 3: EFFECTS OF THE ETHANOLIC EXTRACTS OF STEM AND LEAF OF PEPEROMIA PELLUCIDA ON ACETIC ACID-INDUCED WRITHING IN MICE. Peperomia pellucida is an annual, shallow-rooted herb that belongs to the family Piperaceae (Ghani, 1998). Abstract :Peperomia pellucida (L.) Kunth. Aziba PI, Adedeji A, Ekor M, Adeyemi O (2001). Molecular and Cellular Biochemistry 125: 11-18, 1993. Aerial part of this plant is traditionally used as a medicine in Indonesia such as dizziness, headache, fever, and stomach ache. Flowers of India. Sesquiterpenes appear to be the major chemical constituents in the essential oils. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. 1-4. J Ethnopharmacol. Peperomia pellucida and Cyperus esculentuslocally found plant used for anti-diarrhoeal activity using standard animal model. 2007; http://www.geocities.com/mmsi1902/herbal_aware.htm. Peperomia pellucida, Hypoglycemic activity, Anti-inflammatory activity, Analgesic activity. You should talk with your health care provider for complete information about the risks and benefits of using this product. Correlation analysis showed that phenolic compounds have a role as antioxidant and ACE inhibitor. Garcia-Martinez C, Lopez-Soriano FJ, and Argiles JM. The plant species has a history of ethnomedicinal use. Analgesic treatment was observed carefully and mentionable activities were evaluated. of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats. Values were expressed in Mean ± Standard Error. Chinese Bencao; Shanghai Science & Technology Press: Shanghai, 1999; 3: 422. Isolated phytosterols include campesterol and stigmasterol.Aqil 1993, Aqil 1994, Bayma 2000, da Silva 1999, dos Santos 2001, Manalo 1983, Moreira 1999, Oliveros-Belardo 1967, Ragasa 1998, Xu 2006. 2006 Nov; 9(6):659-665. Review. "Analgesic activity of, Bojo AC, Albano-Garcia E , Pocsidio GN (1994). 1999 May 12; 281(18): 1722-1727. The plant species interferes with prostaglandin synthesis. The animals used in this study were cared in accordance with the guidelines on animal experimentation of our institute. Sheikh S, Sikder S, Paul SK, Hasan AMR, Rahaman MM and Kundu SP: Hypoglycemic, Anti-Inflammatory and Analgesic activity of Peperomea pellucida (L.) Hbk (Piperaceae). Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, McFarlin BK, Timmerman KL, Coen PM, Felker J, Talbert E. Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4. It can be used to diagnose prediabetes and diabetes. http://www.flowersofindia.in/catalog/ slides/Shiny%20Bush.html. Antifungal activity has been documented for arylpropanoids such as the apiols. 17, Authors: com/plants/2180.htm] . The oral administration of both doses of Peperomia pellucida extractsignificantly (p<0.001) inhibited writhing response induced by acetic acid in a dose dependent manner compared. Lecturer, Department of Pharmacy, Bangladesh Institute of Medical Science (BIMS), N/23, Nurjahan Road, Mohammadpur Dhaka-1207, Bangladesh, DOI: CurrOpinClinNutrMetab Care. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This information relates to an herbal, vitamin, mineral or other dietary supplement. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats. Anti-inflammatory, chemotherapeutic, and analgesic properties have been found in crude extracts of P. pellucida. TABLE 3: EFFECTS OF THE ETHYL ACETATE EXTRACTS OF STEM AND LEAF OF PEPEROMIA PELLUCIDA ON ACETIC ACID-INDUCED WRITHING IN MICE. One study reported that anti-inflammatory activity may vary depending on the plant's development phases. It grows in moist habitat and is found throughout the major parts of India. Herbal materials susceptible to contamination during processing and storage which can shortens their shelf life. of the crude extract of Peperomia pellucida. 4: PERCENT OF INHIBITION EFFECTS OF THE ETHANOLIC EXTRACTS OF STEM AND LEAF OF PEPEROMIA PELLUCIDA  ON ACETIC ACID-INDUCED WRITHING IN MICE. This plant has externally used as a facial rinse for complexion problems. Peperomia pellucida is also used in traditional Ayurvedic medicine 6. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. The same reference documents a root decoction for treatment of fevers and mashed aerial parts applied topically or used as dressing for wounds.Muñoz 2000, P. pellucida has been used for treating abdominal pain, abscesses, acne, boils, colic, fatigue, gout, headache, renal disorders, and rheumatic pain, and to treat breast cancer, impotence, measles, mental disorders, and smallpox. Since it inhibits the activity of the hormone sensitive lipases in adipose tissue and suppresses the release of free fatty acids. Epub 2010 Apr 13. Cultivation. Apart from the regulation of carbohydrate metabolism, insulin also plays an important role in the metabolism of lipids. Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. The mice were feed with standard pellet diet taken from Jahangirnagar University, Dhaka and water ad libitum. In northeastern Brazil, the plant has been used to lower cholesterol; in Guyana, it has been used as a diuretic and to treat proteinuria; and in the Amazon region, it has been used as a cough suppressant, diuretic, and emollient, and to treat cardiac arrhythmia.Arrigoni-Blank 2002, Bayma 2000, de Fatima 2004, Numerous chemical investigations, primarily on the essential oils of the plant, are found in medical literature. Although the plant can cause asthma-like symptoms in patients with known hypersensitivity reactions to the species, no clinical data have yet been reported on human toxicity. It is characterized by its fleshy and heart-shaped leaves, succulent stems, shallow roots and minute flowers, which eventually grow into numerous tiny seeds attaching on the cord-like spikes 3 . This information is not specific medical advice and does not replace information you receive from your health care provider. 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